Enhanced efficacy of sequential administration of Albendazole for the clearance of Wuchereria bancrofti infection: Double blind RCT.
Identifieur interne : 001E32 ( Main/Exploration ); précédent : 001E31; suivant : 001E33Enhanced efficacy of sequential administration of Albendazole for the clearance of Wuchereria bancrofti infection: Double blind RCT.
Auteurs : R L De Britto [Inde] ; P. Vanamail [Inde] ; T. Sankari [Inde] ; G. Vijayalakshmi [Inde] ; L K Das [Inde] ; S P Pani [Malaisie]Source :
- Tropical biomedicine [ 0127-5720 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Albendazole (administration et posologie), Animaux, Association de médicaments (), Diéthylcarbamazine (administration et posologie), Doxycycline (administration et posologie), Femelle, Filaricides (administration et posologie), Filarioses (traitement médicamenteux), Humains, Mâle, Méthode en double aveugle, Résultat thérapeutique, Wuchereria bancrofti (), Études de suivi.
- MESH :
- administration et posologie : Albendazole, Diéthylcarbamazine, Doxycycline, Filaricides.
- traitement médicamenteux : Filarioses.
- Adulte, Adulte d'âge moyen, Animaux, Association de médicaments, Femelle, Humains, Mâle, Méthode en double aveugle, Résultat thérapeutique, Wuchereria bancrofti, Études de suivi.
English descriptors
- KwdEn :
- Adult, Albendazole (administration & dosage), Animals, Diethylcarbamazine (administration & dosage), Double-Blind Method, Doxycycline (administration & dosage), Drug Therapy, Combination (methods), Female, Filariasis (drug therapy), Filaricides (administration & dosage), Follow-Up Studies, Humans, Male, Middle Aged, Treatment Outcome, Wuchereria bancrofti (drug effects).
- MESH :
- chemical , administration & dosage : Albendazole, Diethylcarbamazine, Doxycycline, Filaricides.
- drug effects : Wuchereria bancrofti.
- drug therapy : Filariasis.
- methods : Drug Therapy, Combination.
- Adult, Animals, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Middle Aged, Treatment Outcome.
Abstract
Till today, there is no effective treatment protocol for the complete clearance of Wuchereria bancrofti (W.b) infection that causes secondary lymphoedema. In a double blind randomized control trial (RCT), 146 asymptomatic W. b infected individuals were randomly assigned to one of the four regimens for 12 days, DEC 300 mg + Doxycycline 100 mg coadministration or DEC 300 mg + Albendazole 400 mg co-administration or DEC 300 mg + Albendazole 400 mg sequential administration or control regimen DEC 300 mg and were followed up at 13, 26 and 52 weeks post-treatment for the clearance of infection. At intake, there was no significant variation in mf counts (F(3,137)=0.044; P=0.988) and antigen levels (F(3,137)=1.433; P=0.236) between the regimens. Primary outcome analysis showed that DEC + Albendazole sequential administration has an enhanced efficacy over DEC + Albendazole co-administration (80.6 Vs 64.7%), and this regimen is significantly different when compared to DEC + doxycycline co-administration and control (P<0.05), in clearing microfilaria in 13 weeks. Secondary outcome analysis showed that, all the trial regimens were comparable to control regimen in clearing antigen (F(3, 109)=0.405; P=0.750). Therefore, DEC + Albendazole sequential administration appears to be a better option for rapid clearance of W. b microfilariae in 13 weeks time. (Clinical trials.gov identifier - NCT02005653).
PubMed: 26691247
Affiliations:
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In a double blind randomized control trial (RCT), 146 asymptomatic W. b infected individuals were randomly assigned to one of the four regimens for 12 days, DEC 300 mg + Doxycycline 100 mg coadministration or DEC 300 mg + Albendazole 400 mg co-administration or DEC 300 mg + Albendazole 400 mg sequential administration or control regimen DEC 300 mg and were followed up at 13, 26 and 52 weeks post-treatment for the clearance of infection. At intake, there was no significant variation in mf counts (F(3,137)=0.044; P=0.988) and antigen levels (F(3,137)=1.433; P=0.236) between the regimens. Primary outcome analysis showed that DEC + Albendazole sequential administration has an enhanced efficacy over DEC + Albendazole co-administration (80.6 Vs 64.7%), and this regimen is significantly different when compared to DEC + doxycycline co-administration and control (P<0.05), in clearing microfilaria in 13 weeks. Secondary outcome analysis showed that, all the trial regimens were comparable to control regimen in clearing antigen (F(3, 109)=0.405; P=0.750). Therefore, DEC + Albendazole sequential administration appears to be a better option for rapid clearance of W. b microfilariae in 13 weeks time. (Clinical trials.gov identifier - NCT02005653).</div></front></TEI><affiliations><list><country><li>Inde</li><li>Malaisie</li></country></list><tree><country name="Inde"><noRegion><name sortKey="De Britto, R L" sort="De Britto, R L" uniqKey="De Britto R" first="R L" last="De Britto">R L De Britto</name></noRegion><name sortKey="Das, L K" sort="Das, L K" uniqKey="Das L" first="L K" last="Das">L K Das</name><name sortKey="Sankari, T" sort="Sankari, T" uniqKey="Sankari T" first="T" last="Sankari">T. Sankari</name><name sortKey="Vanamail, P" sort="Vanamail, P" uniqKey="Vanamail P" first="P" last="Vanamail">P. Vanamail</name><name sortKey="Vijayalakshmi, G" sort="Vijayalakshmi, G" uniqKey="Vijayalakshmi G" first="G" last="Vijayalakshmi">G. Vijayalakshmi</name></country><country name="Malaisie"><noRegion><name sortKey="Pani, S P" sort="Pani, S P" uniqKey="Pani S" first="S P" last="Pani">S P Pani</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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